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Orthopaedics and Traumatology: research

Research at the SJD Barcelona Children's Hospital Department of Orthopaedics and Traumatology is focused on translational research.

Management and research team

Lines of research

Projects

  1. ACHieve: A multi-center, longitudinal, observational study of children with achondroplasia (2019 - on-going).
  2. AccomplisH: A Phase 2, multicenter, double-blind, randomized, placebo-controlled, dose escalation trial evaluating safety, efficacy, and pharmacokinetics of subcutaneous doses of TransCon CNP administered once weekly for 12 months in prepubertal children with achondroplasia (“Study”) (2019 - on-going).
  3. BIOMARIN 111-302. SUBINVESTIGATOR. A Phase 3, Open-Label Long Term Extension Study to Evaluate the Safety and Efficacy of BMN 111 in Children with Achondroplasia (2019 - on-going).
  4. BIOMARIN 111-301. SUBINVESTIGATOR. Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy and Safety of BMN 111 in Children with Achondroplasia (2018 - on-going).
  5. BIOMARIN 111-901. SUBINVESTIGATOR. A Multicenter, Multinational, Clinical Assessment Study for Pediatric Patients with Achondroplasia (2017 - on-going).
  6. Effect of Denosumar in the Treatment of Giant Cell Tumours (2019 - on-going).
  7. Stratification of patients with 'severe' vascular malformations into risk groups: indicators of severity and progression according to phenotype/genotype/quality of life/PROs (2019 - on-going).
  8. “Lost in time” study: Updating the content and clinical accessibility of the Prosthetic Upper Limb Functional Index (2019 - 2020).
  9. Populational study of traumatic lesions associated with the use of electric scooters (2019 - 2020).
  10. Functional and aesthetic predictive factors of preaxial polydactyly (2016 -  on-going).
  11. Predictive factors of epicondyle fractures (2019 - 2020).
  12. RECREGUI project: multicentre study on guided growth (2018 -  on-going).
  13. RIOPed project: prospective, multicentre study of osteoarticular infection in Paediatrics. Spanish Society of Paediatric Infectious Diseases SEIP, Spanish Society of Paediatric Rheumatology SERPE, Spanish Society of Infectious Diseases and Clinical Microbiology SEIMC, Spanish Society of Rheumatology, SECOT, and SEOP (2015 -  on-going).
  14. Validated Spanish translation of the Reach Out Paediatric Functionality Scale (2018 - 2020).
  15. Vascularisation of the sciatic nerve. Anatomical cadaver study. University of Barcelona (2019 - 2021).
  16. Health Research Fund (FIS) Grant RECREGUI. Guided knee growth. PI Dr César G. Fontecha.
  17. FIS Grant Randomised clinical trial to compare the effectiveness and compliance of the night-time and day-time corset for the treatment of idiopathic scoliosis in adolescents.PI Dr Alejandro Peiró.
  18. FIS Grant Stratification of patients with 'severe' vascular malformations into risk groups: indicators of severity and progression according to phenotype/genotype/quality of life/PROs. PI Dr Eulàlia Baselga. CI Dr Laura M. Pérez-López.
Participation in international study groups
  • Member of the Spanish Sarcoma Research Group (GEIS). Spanish representative in the EUROWING PROJECT.
  • Children’s Spine Foundation Study Group. PSSG Registry.
  • EPOS Infection Study Group 2020.
  • EPOS Tumor Study Group 2020.
  • Children’s Spine Foundation Study Group 2020.
  • Scientific Committee Lead Advisor. MPS-Lysosomals Association.
  • Pompeu Fabra University. Barcelona Centre for New Medical Technologies (BCN Med Tech). Computer simulation project with finite elements of physeal growth.
  • Catalan Institute of Nanoscience and Nanotechnology (ICN2). Project to develop regenerative medicine implants for cartilage lesions.
  • Vall d’Hebron Research Institute. Scientific collaboration on experimental surgery projects with large animals.
  • Alberta Children’s Hospital (Canada). Collaborative project on spinal surgery.
  • AOFoundation (European Society of Osteosynthesis). Upper limb fractures registry.
  • Bloorview Research Institute, Bloorview Children's Hospital Foundation Chair in Paediatric Rehabilitation.
  • Department of Physical Therapy, University of Toronto. PUFI-2 pediatric upper limb functional scale development. Aplasia functionality scale.
  • Birmingham Children’s Hospital. NHS Foundation Trust. Reach Out pediatric upper limb functional scale development. 

Scientific publications

- A meta-analysis of bone morphogenetic protein-2 versus iliac crest bone graft for the posterolateral fusion of the lumbar spine.
- Elbow flexion reconstruction with nerve transfer or grafting in patients with brachial plexus injuries: A systematic review and comparison study.
- ¿Están los Niños Seguros en los Castillos Hinchables? [Are Children Safe in Inflatable Castles?]-
Evaluation by ultrasound of the hips of babies carried in baby carriers.
- Evaluación del impacto del Documento de Consenso Español sobre el abordaje de las Infecciones Osteoarticulares a través de la Red de Infecciones Osteoarticulares Pediátricas (RIOPed) [Evaluation of the impact of the Spanish Consensus Document about the Osteoarticular Infections approach via the Paediatric Osteoarticular Infections Network (RIOPed)].
- Fracture of the radial neck following elbow subluxation in children, Jeffery type II lesion. A new concept of fixation.
- Frequency and characteristics of congenital intraspinal abnormalities in a cohort of 128 patients with congenital scoliosis.
- Fibroqueratoma periungueal adquirido en la edad pediátrica, a propósito de un caso [Periungual fibrokeratoma in children, a case report].
- Knee Arthritis in Children: When Can It Be Safely Treated With Needle Joint Aspiration? A Large Children's Tertiary Hospital Study.
- May we Further Reduce Dose in the Assessment of Full Spine Radiography in Children?
- Osteoarticular infections: Blood as a determinant factor in the isolation of Kingella kingae.
- Osteopoikilosis with Germline LEMD3 mutation mimicking bone metastases in a girl with a concurrent secreting mixed germ cell tumor (the "Work").
- Pedicle screw instrumentation in scoliosis surgery: on site simulation data on accuracy and efficiency with different techniques.
- Quality, Safety, and Value of Innovating Classic Operatives Techniques in Scoliosis Surgery: Intraoperative Traction and Navigated Sequential Drilling.
- Sagittal Balance in Adolescent Idiopathic Scoliosis Managed With Intraoperative Skull Femoral Traction.
- Staged instrumentation with magnetically controlled growing rods in early-onset scoliosis: indications and preliminary outcomes.
- Surgical technique and outcomes for bilateral humeral lengthening for achondroplasia: 26-year experience.
- Elbow flexion reconstruction with nerve transfer or grafting in patients with brachial plexus injuries: A systematic review and comparison study.
- MRI of Rhabdomyosarcoma and Other Soft-Tissue Sarcomas in children.
- Septic Arthritis due to Neisseria meningitidis Serogroup W in Toddlers.
- Neisseira meningitidis Serogroup W causing primary meningococcal septic arthritis in a toddler and review of the literature. Journal of Medical Clinical Case Reports. 2020.
- La tuberculosis osteoarticular en la edad pediàtrica [Osteoarticular tuberculosis in the paediatric age group]. Rev Esp Cir Ortop Traumatol. 2020.
- El niño maltratado [The abused child]. Melisa Stitzman, Ortopedia y Traumatología Infantil para Residentes [Paediatric Orthopaedics and Traumatology for Residents]. SEOP (book chapter).
- Errores en Ortopedia Pediátrica. Cómo realizar una adecuada exploración ortopédica [Errors in Paediatric Orthopaedics. How to perform an adequate orthopaedic examination]. César Galo García Fontecha, Luis González Trapote (book chapter).
- Malformaciones congénitas [Congenital malformations]. Laura M. Pérez López, Marisa Cabrera González, Diego Gutiérrez de la Iglesia, Ortopedia y Traumatología Infantil para Residentes [Paediatric Orthopaedics and Traumatology for Residents]. SEOP (book chapter).
- Tumores Óseos Malignos en la Infancia y la Adolescencia [Malignant Bone Tumours in Childhood and Adolescence]. Ferran Torner Rubies.

Theses

Defended

Estudio Clínico de la Polidactilia Preaxial. Factores pronóstico del resultado quirúrgico [Clinical Study of Preaxial Polydactyly. Prognostic factors for surgical outcome].
Doctoral candidate: Laura M. Pérez López
Directors: Prof. Manel Llusá
University: Universitat de Barcelona
Rating: Excellent Cum Laude. International mention.

In progress

Estudio comparativo de la marcha postoperatoria en artroplastia total de cadera. Abordaje anterior directo vs. Abordaje posterolateral [Comparative study of postoperative gait in total hip replacement. Direct anterior approach vs. posterolateral approach]
Doctoral candidate: Jorge Núñez Camarena
Directors: Dr C. García Fontecha, Dr A. Hernández
University: Autonomous University of Barcelona (UAB)
Ethics committee: PR(ATR)120/2015

Estudio y evaluación de las fracturas y refracturas de antebrazo en edad pediatrica, elaboración de protocolo para la prevención de las refracturas [Study and evaluation of fractures and repeat fractures of the forearm in the paediatric age group, creation of a protocol to prevent repeat fractures]
Doctoral candidate: Melisa Stitzman Wengrowicz

Aplicación de nuevas tecnologías al método Ponseti [Application of new technologies to the Ponseti method]
Doctoral candidate: Laia Giménez Canales

Directed

Estudi prospectiu multicèntric de creixement guiat de les extremitats inferiors en nens. Influència de variables independents en el resultat final [Prospective multicentre study of guided growth of the lower limbs in children. Influence of independent variables on the final outcome].
Doctoral candidate: Maria Jurado Ruiz
Directors: Dr César García Fontecha, Dr Màrius Aguirre Canyadell
University: Autonomous University of Barcelona (UAB)
Reference: MBA-Institute

Penetració òssia dels antibiòtics en la infecció òssia en l'esquelet inmadur. Estudi farmacocinètic en model animal [Bone penetration of antibiotics in bone infections in the immature skeleton. Pharmacokinetic study in an animal model].
Doctoral candidate: Porcel Vázquez, Juan Antonio
Directors: Dr César Galo García Fontecha, Dr Pere Soler Palacín
University: Autonomous University of Barcelona (UAB)
Reference: SCCOT-2013-01, FIS 2013-2015

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