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SJD Barcelona Children's Hospital

Passeig Sant Joan de Déu, 2, 08950 Esplugues de Llobregat

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High-grade diffuse midline glioma K27M mutaded (DIPG)

DIPG (diffuse intrinsic pontine glioma) is the most common brainstem tumour found in children, a highly sensitive portion of the brain vital for human beings. 

Description of the pathology

As with the majority of growth tumours, it is not known why these malignant cells specifically invade the brainstem so diffusely. It normally occurs in children between 5 and 10 years of age.

The symptoms are fairly characteristic, consisting of alterations in facial movement, difficulty in swallowing and walking, and weakness in the arms or legs. These symptoms commonly develop within a few weeks. Unfortunately, there is no curative treatment for this disease.


DIPG is a disease that is diagnosed on the basis of the typical symptoms described above and from well-defined radiological criteria in an MRI scan. To this day, a biopsy is not essential for confirming diagnosis. However, centres of reference such as the SJD Barcelona Children's Hospital, which are engaged in research projects and/or clinical trials where the analysis of tumour tissue is essential, value performing this procedure at the time of diagnosis.

A biopsy usually confirms the existence of a glial-type tumour. Molecular analysis of these tumours has revealed that in the majority (80% of cases) a mutation of the K27M gene is identified in two variants, the H3.3 (60% of cases) and the H3.1 (20% of cases). These molecular changes, in combination with other genetic alterations (e.g. p53, ACVR1, PDGFR), are fundamental in the onset, development and progression of the disease.


Focal radiation therapy (targeting the tumour) is the only treatment that achieves a reduction in the tumour size and improvement in symptoms for the majority of DIPG patient.

SJD Barcelona Children's Hospital offers biopsies to patients we diagnose. From these samples we try to establish cell lines and animal models.

We also characterise molecular markers in lesions with the aim of identifying potential therapeutic targets.



Treated cases since 2010


Cell lines of research into DIPG


Clinical immunotherapy trial

A clinical trial using dendretic cell-based vaccines is currently underway. Patient recruitment has been completed and the responses obtained are under evaluation. The expected outcomes may form the basis of future versions of this treatment.

Research at SJD Barcelona and worldwide

There is a series of clinical trials currently underway at various centres worldwide which are exploring new treatments targeting this disease.

Participation of families in the research

Numerous families of patients affected by DIPG remain in contact with the hospital and are actively participating in the capture of data. The Fondo Alicia Pueyo is one of these groups and it also provides information to families.

“At birth, Daniel began to have trouble breathing and almost did not move. The operation he needed could not be done in Nigeria. Now Daniel can breathe and he does not stand still for a minute, he is a happy child.”

Mother of Daniel operated for a Congenital Pulmonary Airway Malformation (CPAM)

"Our work is to ensure the continuous learning of our residents is based on experience and has a scientific basis, with accompaniment and tutoring of the process.”

Nursing resident tutors Nursing resident tutors at SJD Barcelona Children’s Hospital

"he tutors transmit a vocation and respect for specialising as a midwife or male midwife. You learn a lot, there is a high volume of activity and we handle complex cases. The residency is very comprehensive and supported.”

Carlos Aulló currently a male midwife at SJD Barcelona Children's Hospital, resident from 2018-2019

"Very emotional situations occur during childbirth, and also in consultations. Being there in those moments, working in that context, and sharing it with your colleagues and experienced professionals is a comprehensive learning experience.”

Raquel Campo first-year resident midwife (R1) at SJD Barcelona Children's Hospital

"Learning is intense and accelerated, and there is close accompaniment of the women, even in a pandemic context. We make a real effort to make sure all the women we care for feel support when they come to the Hospital.”

Roser Romero former resident and currently midwife at SJD Barcelona Children's Hospital